Title : Polymorphisms in the vitamin D receptor gene are associated with reduced rate of 4 sputum culture conversion in multidrug - resistant tuberculosis patients in South Africa
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چکیده
TITLE PAGE 1 Version: April 11, 2017 2 3 Title: Polymorphisms in the vitamin D receptor gene are associated with reduced rate of 4 sputum culture conversion in multidrug-resistant tuberculosis patients in South Africa 5 6 Authors: Matthew J Magee (1), Yan V. Sun (2), James CM Brust (3), N. Sarita Shah 7 (5), Yuming Ning (3), Salim Allana (2), Angela Campbell (2), Qin Hui (2), Koleka 8 Mlisana (4), Pravi Moodley(4), Neel R Gandhi (2,6,7) 9
منابع مشابه
Polymorphisms in the vitamin D receptor gene are associated with reduced rate of sputum culture conversion in multidrug-resistant tuberculosis patients in South Africa
BACKGROUND Vitamin D modulates the inflammatory and immune response to tuberculosis (TB) and also mediates the induction of the antimicrobial peptide cathelicidin. Deficiency of 25-hydroxyvitamin D and single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene may increase the risk of TB disease and decrease culture conversion rates in drug susceptible TB. Whether these VDR SNP...
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BACKGROUND Polymorphisms in the gene that encodes the vitamin D receptor (VDR) may influence the host response to Mycobacterium tuberculosis infection. METHODS In a Peruvian community with a high incidence of tuberculosis (TB), VDR TaqI and FokI polymorphisms were compared among 103 patients with pulmonary TB and 206 matched healthy control subjects. Associations of VDR polymorphisms with tre...
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Objective(s) Deregulation of the immune system through allied factors and cytokine responses are thought to be important contributors to the pathogenesis of asthma. Vitamin D3 and its nuclear receptor appear to be factors that maybe involved in regulating immune responses during the progression of asthma. The aim of this study was to investigate the association between polymorphisms in intron ...
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BACKGROUND The majority of patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are co-infected with HIV, but the radiographic features of MDR-TB and their relationship with time to sputum culture conversion in the antiretroviral therapy era have not been described. METHODS We reviewed baseline chest radiographs for 56 patients with MDR-TB from a rural area of South Africa....
متن کاملبررسی ارتباط پلیمورفیسمهای شایع ژن پذیرنده ویتامین (VDR) D با استعداد ابتلاء به سل ریوی
Background and Aim: In addition to exposure to Mycobacterium tuberculosis (MTB), development of tuberculosis is influenced by environmental and host genetic factors, and clinical disease only occurs in less than 10% of the infected individuals. Vitamin D metabolism leads to activation of macrophages and restricts the intracellular growth of mycobacterium. This effect may be influenced by poly...
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